Journal: Bioactive Materials

Article Title: Oxygen-vacancy-engineered t-ZnO-CeO 2 Schottky junction enhanced infectious bone regeneration via photoelectric-photocatalytic effects-induced mitochondrial quality control

doi: 10.1016/j.bioactmat.2026.04.042

Figure Lengend Snippet: Analysis of RNA changes and metabolite alterations in 3D-printed scaffolds. (a) Schematic representation depicting the process of transcriptomics analysis and metabolomic analysis in rBMSCs cultured with the 3D-printed scaffolds. (b) Heatmap of differentially expressed genes (DEGs) in PLLA/tZC + NIR groups vs NIR groups (n = 3). (c) Volcano diagram of the gene characteristics of rBMSCs. (d, e) GO enrichment analysis of the (d) up-regulated terms and (e) down-regulated terms among DEGs. (f, g) KEGG enrichment analysis of the (f) up-regulated and (g) down-regulated pathways among DEGs. (h) PCA analysis of untargeted metabolomics of rBMSCs in PLLA/tZC + NIR groups vs NIR groups (n = 5). (i) Volcano diagram of the metabolite characteristics of rBMSCs. (j) The heatmap of differentially expressed metabolites (DEMs). (k) Sankey diagram of pathways for DEMs.

Article Snippet: For metabolomic profiling, the samples were sent to Bioprofile Co., Ltd. (Shanghai, China) for analysis.

Techniques: Transcriptomics, Metabolomic, Cell Culture

Journal: Poultry Science

Article Title: Mechanism of Scutellaria baicalensis extracellular vesicles in attenuating Mycoplasma gallisepticum -induced inflammation via TRPC1 - STIM1/ORAI1 channel inhibition

doi: 10.1016/j.psj.2026.106773

Figure Lengend Snippet: Metabolomics analysis. (A) Metabolite volcano plot. The x-axis displays the log2 of fold change, while the y-axis shows the -log10 of the significance P-value. Significantly differential metabolites: those meeting FC > 2 and P value < 0.05 are depicted in orange; those meeting FC < 0.5 and P value < 0.05 are depicted in purple. Non-significant metabolites are depicted in grey. (B) Differential metabolite clustering heatmap. Relative abundance is depicted by color intensity: red indicates higher expression, blue lower expression. Columns represent samples, rows denote metabolite names. The clustering tree on the left displays differentiated metabolites. (C) Venn diagram. The sum of numbers within each circle represents the total differentiated metabolites for that comparison pair. Overlapping areas indicate metabolites common to both comparison groups. (D) Enrichment factor plot: Enrichment is measured by the Rich factor, P-value, and the number of metabolites enriched in this pathway. The Rich factor denotes the ratio of enriched differentially expressed metabolites to annotated metabolites in the pathway. A higher Rich factor indicates greater enrichment. P-values typically range from 0 to 0.05; values closer to zero denote more significant enrichment. Each point represents a metabolic pathway, with the x-axis displaying Rich factor values for different pathways and the y-axis showing the enriched pathways. Dots indicate the number of metabolites within each pathway. Color corresponds to P-value significance.

Article Snippet: In collaboration with Paisen Bio (Shanghai, China; http://www.personalbio.cn/ ), cell samples were submitted to Metabolon for non-targeted metabolomics analysis.

Techniques: Expressing, Comparison

Journal: Metabolomics

Article Title: Comparison of fecal and plasma metabolite correlations following nutrition or exercise interventions

doi: 10.1007/s11306-026-02463-z

Figure Lengend Snippet: Predicted plasma and fecal molecular fingerprints between Gut2Brain (G2B, orange) and Food4Gut (F4G, blue) studies utilizing acquired reversed-phase separated positive-ionization MS/MS data. Bars indicate relative distributions of top 10 commonly assigned ClassyFire chemical classes and sum of unique classes from plasma and fecal metabolomics data using Sirius 5.8.5 and integrated CSI: FingerID

Article Snippet: OK, VK, AFB, TM and KH are affiliated with Afekta Technologies Ltd., a company providing metabolomics services.

Techniques: Clinical Proteomics, Tandem Mass Spectroscopy